MITOCHONDRIAL INNER MEMBRANE INTERACTOME
p5.js Kinetic Simulation
Pathobiology Presets
Substrate & Enzymatic Parameters
Biochemical Counterfactual Analysis
Healthy Neuronal Basal State
High oxygen availability and intact ETC complex activities maintain a robust proton gradient (ΔΨm ~ -160mV). Protons drive high-speed rotation of ATP Synthase F1 head, generating peak ATP synthesis required for neuronal ion pumping and synaptic transmission.
The "Single Missing Molecule" Mechanism
Whether triggered by mechanical shear (TBI), toxic aggregates (Alzheimer's/Parkinson's), or profound metabolic strain, brain dysfunction maps directly to an ATP bioenergetic charge collapse. Without adequate ATP, Na+/K+ pumps fail, leading to membrane depolarization and excitotoxic damage.
CANONICAL METRIC STATE:
ATP Rate: 950 µM/s | Ratio: 10.0