🧠 rs-fMRI Brain Connectome & Neuromodulation Lab

Acupuncture Somatic-Vagal Afferent Simulation
DMN Coherence: 0.82 (Hyper-coupled)
CEN Coupling: 0.34
DMN-CEN Antagonism: -0.48
Est. HAM-D: 24.2 (Severe MDD)
Functional Connectome Topology (rs-fMRI 0.01–0.08 Hz) MDD Baseline
Protocol Milestones:
DMN (Rumination / Self-Ref)
CEN (Executive / Task)
Salience (AI/dACC Switch)
Limbic (Amygdala Affect)
Deliver Somatic Afferent Pulse:
BOLD Dynamics & Matrices
Cross-Correlation Heatmap (r) Hub: PCC
Real-time BOLD Signals (Phase Sync)
Pathology: Excessive DMN synchrony (mPFC-PCC hypercoupling) drives rumination. CEN cognitive control is decoupled.
MetricCurrentHealthy Ref
Modularity Index (Q)0.480.62 ± 0.05
DMN Coherence0.820.45 ± 0.08
CEN Coherence0.340.72 ± 0.06
Salience Switching Gain0.420.70 ± 0.04
Model grounded in clinical rs-fMRI acupuncture neuroimaging trials (n=48 MDD cohort). Bandpass filtered 0.01–0.08 Hz. Dataset: Somatic/Vagal Neuromodulation Study
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