Live Kinetic Molecular Simulation
Real-time Particles & Degradation
Fermentation Duration
4 Days
Roasting Temp (°C)
120°C
Alkalization (Dutch pH)
pH 5.5
Cardiovascular Bioactivity Model
ACTIVE eNOS MODELFlavanol Retention
100%
12.5 mg/g
eNOS Activity
100%
Endothelial Nitric Oxide
FMD Δ (%)
+2.8%
Vasodilation Response
Active Monomers
95%
(-)-Epicatechin Ratio
Thermal Epimerization
Roasting (>120°C) thermally converts bioavailable (-)-epicatechin into its less active epimer (-)-catechin, drastically reducing vascular receptor affinity.
Alkaline Cleavage (Dutched)
Raising pH > 7.0 (Dutching) causes irreversible oxidative cleavage of procyanidin dimers/trimers into inactive high-molecular-weight brown melanoidin polymers.
Retention: 32.5% | FMD Increase: +1.8%