Interactive DNA Sequence Pad
BRCA1 / Genome Atlas Cluster 4
Select a position along the 25-base genomic window or inject a base-pair transition to trigger the AlphaGenome & AlphaMissense pattern matching engine.
Reading Frame: Exon 11 / Exonic Splicing Enhancer (ESE)
Chromosomal locus: chr17:43,044,295-43,044,320 (GRCh38/hg38)
Sequence window: 25-mer sliding region centered at codon
Consequence & Therapeutic Match
DeepMind Atlas Inference
Transcriptional Disruption Index
89%
Splicing Motif Conservation Loss
92%
Predicted Phenotype
Exon Splicing Disruption & Transcriptional Suppression
Molecular Consequence
Premature Termination / Truncation
Chromatin Accessibility
-3.42 log2FC (Closed State)
Atlas Validation Cohort
ClinVar (P) / AlphaGenome Catalog
Primary Therapeutic Pathway Candidate
PARP Inhibitor + Targeted Genomic Correction
Synthetic lethality strategy targeting homologous recombination deficiency (Olaparib / Talazoparib pathway).
Active Genomic Research Summary (Durable Artifact)
Scientific Provenance & Discovered Knowledge
Reporting source: The Verge on DeepMind's AI models (including AlphaGenome & AlphaMissense) learning patterns between DNA variation and human biology. The AlphaGenome Atlas catalogues molecular impacts across both coding (2%) and non-coding (98%) regions of human DNA, estimating gene regulation, transcript stability, and therapeutic targets.
Evidence updated September 2026. This tool provides predictive simulation for academic and educational modeling.