Patent Exclusivity & Litigation Milestones Timeline
Years 2020 – 2028
Commercial Revenue Trajectory: Upheld Patent vs. Generic Cliff Erosion
Millions USD / Year
Entresto Patent Claim Portfolio Defense Matrix
Patent Thicket Anatomy
| Patent Identifier | Claim Subject Matter | Core Expiry | Defense Argument | Court Viability |
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Legal Doctrine: Supramolecular Co-Crystal Inventive Step
The UK High Court validated Novartis’s patent EP 2 764 002 covering the trisodium sacubitril-valsartan hemipentahydrate co-crystal. Generic challengers argued that combining two known antihypertensives was routine (obviousness). However, the Court upheld that creating a discrete, stable single-crystal supramolecular complex with enhanced bioavailability constituted a patentable inventive step beyond mere mechanical mixture.