Focused Ultrasound Neuromodulation Simulator | Non-Invasive Addiction Circuit Targeting

Transducer Array & Physics 128-ch Array

Clinical Protocol Preset

Center Frequency (f₀) 650 kHz

          250 kHz (High Penetration)
          1.0 MHz (Tight Focus)
        

Acoustic Power (P_ac) 18.5 W

Duty Cycle (DC) 5.0 %

Pulse Repetition (PRF) 10 Hz

CT Skull Phase Correction

Skull Bone Physics: Human calvarium introduces acoustic velocity mismatch (2800 m/s in cortical bone vs 1540 m/s in brain tissue) causing severe wave defocusing. CT-derived time-reversal beamforming corrects each element's phase to synthesize a sharp millimeter focal point inside the Ventral Striatum.

TARGET: NAc (X: 0.0mm, Y: -12.0mm)

MODE: Non-invasive Transcranial LIFU

🎯 Click or drag crosshair anywhere inside cranial slice to steer acoustic focus

Ventral Tegmental ➔ Nucleus Accumbens Dopamine Burst Telemetry Firing Rate: 1.2 Hz (Suppressed)

Bio-Dosimetry & Safety FDA / IEC 60601

Peak Neg. Pressure

1.15 MPa

Focal spot peak (P-)

Focal Spot (FWHM)

2.40 mm

Lateral resolution

Mechanical Index

1.42

Threshold < 1.90

Thermal Dose

0.08 CEM43

Threshold < 1.00 min

Craving Index Reduction -74.2%

Model based on clinical trial data: 10-minute sonication of Ventral Striatum downregulates hyper-sensitized cue-induced methamphetamine craving.

Mechanism of Action: Focused sound waves generate sub-megapascal acoustic radiation forces on mechanosensitive ion channels (PIEZO2, TRP channels) and astrocytic membranes, interrupting pathological addiction oscillatory synchronization in the reward circuit without neurosurgical incisions or electrode implantation.