Lactase Persistence & Genetic Selection Simulator

Genotype & Dietary Intake LCT / MCM6

Target Genotype Heterozygous (C/T)

Lactose Dose (g) 25 g (1 glass milk)

MCM6 -13910: 5'-AGATATGAG-3'

Evolutionary Sweep Params

Selection Coefficient (s) 0.05 (Pastoralism)

Generations Simulated 300 gens (~9,000 yrs)

Demographic Anchor

Brush Cleavage 82% Absorbed in jejunum

Colonic Ferment 18% Microbial gas & H₂

Blood Glucose Δ +22.4 mg/dL Peak postprandial

Allele Freq (t) 0.68 Gen 300

Intolerance Rate 70% Global Baseline

Lactose (Disaccharide)

Glucose + Galactose

Colonic Fermentation / H₂

Microvilli Epithelium: Moderate Lactase (CT Heterozygote) Osmotic Load: Mild (4.5g fermented)

Region / Population	Adult Intolerance %	Persistence %	Primary Causative Allele	Dietary Pastoralism Origin