Magnesium Bioavailability & Clinical Evidence Simulator

Regimen & Patient Baseline

Bisglycinate

Primary Clinical Target

Chemical Form (Salt / Chelate) 14.1% Elemental Mg

Target Elemental Magnesium 200 mg

50 mg 350 mg (Adult UL) 600 mg

Baseline Dietary Intake 240 mg/day

Deficient (<250) Adequate (320-420) Optimal (>420)

Dosing Strategy

Gastric State & Timing

Physiological Modulators

Vitamin B6 (Pyridoxal 5'-Phosphate Co-administration)

Vitamin D3 Sufficiency (>30 ng/mL)

Proton Pump Inhibitor (PPI) / Hypochlorhydria

Pharmacokinetic Simulator & Physiological Flux

Optimal Bioavailability

Estimated GI Absorption 44.8% ~89.6 mg absorbed

CNS / BBB Uptake Index 1.4x Moderate Neurological Flux

GI Osmotic Load Risk Low (12/100) Minimal loose stool potential

Clinical Effect Size d = 0.58 Moderate Improvement

Dynamic 24-Hour Plasma & CSF Magnesium Concentration Delta

Serum Δ (mg/dL)

CSF / Brain Tissue (Relative)

Osmotic Threshold

Intestinal Transport Partition 68% Active / 32% Passive

■ TRPM6/7 Saturable Channels ■ Paracellular Claudin Flux

Ligand Bio-Activity Glycine (2 Moles)

Glycine functions as an inhibitory neurotransmitter at NMDA receptors and supports core temperature reduction, synergizing with magnesium for sleep latency.

Randomized Controlled Trial (RCT) Evidence Syntheses

Compiled clinical trial endpoints across sleep, migraine prophylaxis, and stress. Baseline deficiency dictates magnitude of effect.

Filter by Outcome:

Study & Citation	Sample (N) & Population	Intervention & Dose	Primary Endpoint Observed	Standardized Effect (Forest Plot)	Key Response Modifiers

*Cohen's d: 0.2 (small), 0.5 (medium), 0.8+ (large). Error bars represent 95% Confidence Intervals from published peer-reviewed meta-analyses.

Comparative Biochemical & Pharmacological Matrix (8 Magnesium Forms)

Evaluating elemental density, water solubility at stomach pH (1.5 - 3.0), absorption pathways, and clinical indications.

Compound Name	Elemental Mg %	Molar Mass (g/mol)	Gastric Solubility	Primary Absorption Route	Chelated Ligand Benefit	Est. Cost / 100mg Mg

Personalized Regimen Analysis & Safety Clearance

Within Safe Upper Intake Tolerances

Supplemental elemental magnesium is below the 350 mg/day adult UL. Osmotic diarrhea and GI distress probability is under 15%.

Total Daily Elemental Inflow

440 mg/day

(240mg Diet + 200mg Supplemental)

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