Neoantigen Immune Synapse & Micro-Clearance
Active Synapse
Lipid nanoparticles deliver 34 synthetic neoantigen payloads to dendritic cells. HLA class I presentation triggers robust clonal expansion of cytotoxic CD8+ T-cells, neutralizing micrometastatic melanoma foci.
CD8+ Cytotoxic Index
92
LNP Transfection Rate
94.8%
Foci Clearance Rate
89.2%
Kaplan-Meier Recurrence-Free Survival (RFS)
mRNA-4157 + Pembro
Pembro Monotherapy
Hazard Ratio (HR)
0.56
Risk Reduction
44%
Combo 36-Mo RFS
78.4%
Control 36-Mo RFS
62.1%
Median RFS (Combo)
Not Reached (>36 mo)