Nutrient Depletion & Reintroduction Simulator

Depletion Duration: 14.0 Years

Reintroduction Meal Target

Vitamin B12 (Cobalamin): Liver stores (~2-5mg) deplete exponentially with a half-life of ~350-400 days. Full depletion manifests around 4-7 years without supplementation.
Heme vs. Non-Heme Iron: Heme iron (animal origin) is directly absorbed via HCP1 with ~15-35% efficiency. Non-heme iron (plant origin) requires enzymatic reduction (Dcytb) and DMT1 transport, with low bioavailability (2-10%) inhibited by phytates.
Neurochemical Reward Circuitry: Acute reintroduction after long depletion triggers intense gustatory dopamine releases in the nucleus accumbens due to primary metabolic receptor signaling.

Tissue & Liver Depletion

B12 Liver Reserves

0.40 µg

Baseline normal: 2000 - 5000 µg

Serum Iron & Ferritin

12.5 µg/dL

Baseline normal: 60 - 170 µg/dL

Zinc Pool Saturation

42.0 %

Optimal cellular saturation: 100%

Omega-3 Index (EPA/DHA)

2.1 %

Target cardioprotective level: >8%

Absorption Efficiency Multiplier

4.5x

High bioavailable Heme Iron + B12 intrinsic factor saturation.

Dopamine Signal Burst

HIGH

Nucleus accumbens reward response.