PDE5 Inhibitor Vascular Dynamics & cGMP Simulator

Time Scrub: 00.0 hrs 48.0 hrs timeline

Dosing Regimen (Tadalafil)

Physiological Variables

Dose Amount 5.0 mg

Baseline Endothelial NO Synthesis 100%

Dynamic Telemetry

Serum Drug Conc.

0.0 ng/mL

PDE5 Inhibition

0.0 %

Intracellular cGMP

1.20 nmol

Intracellular Ca²⁺

100.0 nM

Lumen Diameter

120.0 µm

Microvascular Flow

+0.0 %

MAP Delta (Systemic BP)

-0.0 mmHg

Mechanism: Endothelial Nitric Oxide (NO) stimulates Soluble Guanylyl Cyclase (sGC) to convert GTP into cGMP. cGMP drives Protein Kinase G (PKG) activation, clearing Ca²⁺ ions to relax smooth muscle. PDE5 degrades cGMP. Tadalafil's prolonged half-life (~17.5h) prevents PDE5 degradation, sustaining vasodilation and reducing systemic vascular resistance.