Calculated Crude Yield
78.1%
Overall crude: 1.82 kg
Prep-HPLC Purified API
54.6%
Final Purity: >98.5%
Total Campaign Time
11.4 days
Bottleneck: Prep-HPLC
Direct Cost Per Gram
$142 / g
Commercial Margin: 71.6%
Sequence Aggregation & Coupling Risk Profile
Per-residue steric hindrance, hydrophobicity, and racemization propensity
Unit Operation Schedule & Mass Balance
Validated SPPS Kinetics
| Unit Operation | Duration | Throughput / Mass | Recovery |
|---|
Cost Structure Breakdown ($ / kg API)
$142,000
| Component | Base Cost | With Super AI |
|---|
Prep-HPLC column diameter restricts throughput to 6 runs/day. Upsizing to 300 mm DAC saves 3.2 days.