Dietary Lipid & Bioactive Inputs
2000 kcal
5.0 %
Primary driver of hepatic LDL receptor downregulation.
10.0 %
Upregulates LDLR clearance & suppresses VLDL secretion.
15.0 %
25 g
Binds intestinal bile acids; diverts hepatic cholesterol pool.
2.0 g
Competes with micellar intestinal absorption of cholesterol.
0 mg
10-Year ASCVD Cumulative Cardiovascular Risk Curve
Standard Baseline
Selected Pattern
Projected vascular event probabilities based on cumulative atherogenic ApoB particle exposure.
Hepatic & Intestinal Kinetic Telemetry
Hepatic LDLR Expression
1.35x
vs baseline
Reduced SFA and elevated PUFA increase SREBP-2 cleavage and LDLR density.
Intestinal Cholesterol Absorption
32.4%
fraction
Phytosterols & viscous fibers displace micellar cholesterol in enterocytes.
ApoB Clearance Rate
+38.2%
pools/day
Fractional clearance rate (FCR) of circulating LDL particles via LDLR.
Estimated Bioactive & Polyphenol Impact
Polyphenols
1250 mg
Endothelial NO
+18%
Bile Acid Binding
High
Oxidized LDL Risk
-34%