Molecular Regulatory Circuit (D3.js)
Paradoxical Transcription
Canonical G1 Arrest
28.4%
Oncogenic Rb Flux
0.68
Net Suppression Score
-0.12
Phospho-Rb Ratio
0.72
Phenotype Phase-Plane & Binding Curves
Active Pathway Regime: Paradoxical Rb-Driven Transcriptional Activation. High chromatin co-factor recruitment overrides unphosphorylated Rb's classical cell cycle arrest.
Experimental Perturbations
0.72
0.85
1.00
0.00 µM
Gene Target Promoter Occupancy
E2F Target (Cyclin E1/A2, Proliferation)
43.6%
Rb-Coactivated Loci (Survival/Metabolism)
68.0%
E2F-Rb Repressive Complex Density
28.4%