Gene & Biophysical Parameters
PKD1 Truncating
Live Biophysical Glomerular & Tubular Mesh
Simulation Active
Podocytes / Slit
GBM Layer
Protein / Solute Particles
Primary Cilia
Clinical Telemetry & Biomarkers
Estimated eGFR
78
mL/min/1.73m²
Annual Decline
4.2
mL/min/yr
Protein Expression
25%
Functional Protein
Structural & Biophysical State
Polycystin-1 structural truncation causing disruption of primary cilia mechanosensation
Filtration Barrier Status: Intact glomerular membrane, tubule cystogenesis active
Cyst Volume Index: High (3.8% annual growth)
50-Year eGFR Trajectory Horizon
Age 20 - 70