NATURE BIOTECH 2026

Rentosertib Biological Aging Clock Workbench

Biological Age Delta
-5.8 yrs
Chronological 64.0 → Bio 58.2
Simulated Biological Age
58.2 yrs
Mean of 6 blood-protein models
Biomarker Confidence
94.2%
P-value < 0.001 across panels
Clocks Shifted Direction
6 / 6
All 6 models show rejuvenation
Multi-Clock Blood-Protein Trajectory
Progression of 6 independent biological aging models over treatment weeks
Biological rejuvenation shift detected across all 6 clocks
Key Blood-Protein Biomarker Signatures
Biological Clock Core Protein Marker Expression Shift Age Model Estimate Individual Delta
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