Supplement Absorption & Pharmacokinetics Simulator

Physiological Multicompartment Model

Simulation Parameters

5000 mg
"Almost every rule about when to take a supplement was invented rather than measured. Creatine saturates muscle over days, so the only variable is whether the dose was taken."
— Dr. William Wallace, Ph.D.

Pharmacokinetic Model Output & Saturation Curves Timing Sensitivity: Negligible

1. Gut Lumen (Ingestion) 5000 mg
2. Transporter / Mucosa 95.2% Rate
3. Vascular Systemic Plasma 12.4 mg/L Spike
4. Target Tissue Pool 98.4% Saturation
Tissue Pool Saturation 98.4% Intramuscular Phosphocreatine
Absorption Efficiency 95.2% Net Bioavailability
Days to Steady State 14 Days Full Pool Loading
Physiological Takeaway & Saturation Dynamics
Creatine operates via chronic intramuscular phosphocreatine pool saturation. Intra-day dosing timing has negligible impact on steady-state tissue levels.
Simulation Model Active • Compound: Creatine Monohydrate
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