Sydenham Chorea & Mimicry GAS M-Protein Autoimmune Tool

Molecular mimicry driving basal ganglia motor circuit disinhibition & hyperkinesia

Dual-Pane Molecular Docking & Basal Ganglia Motor Circuit
GAS M-Protein
Cross-reactive IgG
D1/D2 Receptors
Dopamine
Antibody Titer (IgG Concentration) 1:640
Cross-Reactivity Affinity 88%
M-Protein Epitope Mutation M5 Strain
Simulation Time / Speed 1.0x
Pathophysiology Telemetry & Therapeutics
Cross-Reactivity Index
0.88
Chorea Waveform Freq
4.20 Hz
D2R Binding Affinity
88%
CaMKII Activation
Hyperactive
Basal Ganglia Circuit Status: Disinhibited
Indirect pathway suppressed / Direct pathway disinhibited. Excess striatal dopamine receptor stimulation causing choreiform involuntary motion.
Therapeutic Interventions

Pathology & Circuit Proof Surface

Pathway: Indirect Pathway Suppressed
Chorea Freq: 4.20 Hz
Cross-Reactivity: 0.88
CaMKII State: Hyperactivation
Therapeutic Delta: None Applied
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