2D Abdominal Cross-Section
Subcut. Fat
Muscle Wall
Visceral Fat
TOFI Pathophysiology: Even with normal external body appearance (low subcutaneous skinfold layer), deep intra-abdominal visceral fat wraps around vital abdominal organs, releasing pro-inflammatory cytokines into portal circulation.
Biomarker Sensitivity Controls
Height
175 cm
Weight
68 kg
Waist Circumference
86 cm
Subcutaneous Skinfold
12 mm
Visceral Fat Area (VFA)
135 cm²
Triglycerides
180 mg/dL
HDL Cholesterol
38 mg/dL
Fasting Blood Glucose
104 mg/dL
Cardiometabolic Phenotype
Body Mass Index (BMI)
22.2
Normal Mass
Waist-to-Height Ratio
0.49
Sub-threshold (<0.50)
Visceral Fat Status
Elevated Risk (>100 cm²)
High Organ Fat
Lipid Accumulation (LAP)
54.6
High Accumulation
Ectopic Organ Lipid Infiltration
MASLD (Fatty Liver) Risk
High (72%)
Visceral adipocyte lipolysis releases free fatty acids directly into the portal vein (portal hypothesis), promoting hepatic lipid accumulation, steatohepatitis, and altered lipid export.