Interactive Controls:
Click canvas to steer Microglia & spawn ULK1 Kinase Bursts. Drag filopodia to engulf toxic aggregates.
Active Autophagy Running
Amyloid Aggregates
ULK1 Kinase Nodes
Autophagosomes
Lysosomes (p62)
ROS Stress Particles
Aggregates Remaining: 120
Sim Time: 0.0s
Clearance Rate
18.4
pg/min
Microglial phagocytic flux
Autophagosome Eff.
38%
ULK1 initiation index
Microglial State
M1 (Inflammatory)
Cytokine activation balance
Proteostatic Risk
78%
Neural accumulation index
Biophysical Presets 4 Scenarios
Cellular Aging Parameters
35%
Regulates phagophore initiation & microglial autophagy initiation rate.
40%
Governs autophagosome-lysosome fusion & enzymatic degradation efficiency.
75%
Accelerates microglial pro-inflammatory M1 phenotype transition & neurotoxicity.
120 units
Density of toxic protein aggregates present in the neural extracellular space.
Biological Mechanism Insight
Decreased ULK1 expression significantly restricts autophagosome initiation, leading to toxic amyloid accumulation and chronic microglial activation.