Clinical Differential & Workup Navigator for Chronic Severe Underweight

Diagnostic Matrix & Multi-System Mapping

Demographics 22 AFAB

Calculated BMI 15.1 kg/m²

Nutritional Context High / Family Equal

Prior Intervention Dewormer (No Δ)

Clinical Reality Check: Caloric intake meets or exceeds family baseline without weight gain. Parasitic etiology ruled out by empiric non-response. Multi-system presentation strongly indicates systemic malabsorption, hypermetabolism, or connective tissue phenotype rather than primary undernutrition.

Active Presenting Signs & Anatomical Indicators (Click to toggle):

Primary Diagnostic Clusters & Correlated Pathophysiology:

Recommended First-Line Diagnostic Workup Panels:

Investigation	Target Pathology	Clinical Rationale

Physician Consultation Briefing Agenda

PCP Ready

Synthesized agenda designed to prevent diagnostic anchoring (e.g., assuming an eating disorder or non-specific fatigue) and guide standard diagnostic orders.

Primary Care Clinical Briefing: Diagnostic Workup

Patient Profile: 22 AFAB | BMI 15.1 kg/m² | Lifelong severe thinness

PCP Consult Sheet

1. Caloric & Nutritional Context (Addressing Biases)

Adequate / Hyper-intake: Consumes 3 balanced meals daily with rice portions equal to or greater than normal-BMI family members.
Zero Substance Impact: Non-smoker, non-drinker, zero current medications.
Refractory History: Empiric anti-helminthic parasite treatment produced zero clinical response.

2. Phenotypic & Multi-System Presentation

3. Prioritized Differential Diagnoses

4. Specific Requested Diagnostic Orders