Universal Pneumococcal Vaccine Simulator | Capsular Escape vs Pan-Serotype Immunity

Immunization Regimens SELECT ACTIVE TARGET

Unvaccinated 0 Targets

Naive mucosal colonization with rampant bacteremia risk.

No Opsonization

PCV-13 Conjugate 13 Polysacc.

Covers 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 23F.

Capsular Specific

PCV-20 Conjugate 20 Polysacc.

Expanded coverage + 8, 10A, 11A, 12F, 15B, 22F, 33F.

Broad Conjugate

Universal Chimera 100+ Serotypes

Recombinant fusion of conserved surface proteins (PspA + PcsB + PhtD).

Conserved Core Proteins

Historical & Clinical Presets

Universal Vaccine Mechanism: Conserved cell-wall anchoring proteins (PspA, PcsB, PhtD) protrude through polysaccharide capsules. Universal antibodies cross-link these proteins across all 100+ serotypes, initiating complement C3b deposition and rapid macrophage engulfment without serotype replacement risk.

Active Regimen: Universal Protein Chimera

Pan-Serotype Clearance ACTIVE

Universal Protein Target Vaccine Serotype (VT) Escape Serotype (NVT) Resident Macrophage

CLICK / DRAG on canvas to inject target bacteria

Nasopharyngeal Colonization

4.2%

Epithelial mucosal clearance: High

Invasive Disease (IPD) Reduction

98.6%

Meningitis & Sepsis Blockade

Serotype Replacement Risk

0.0%

Capsule-independent immunity

Immunological Parameters

Antibody Titer (IgG Concentration) 100% (High)

Opsonophagocytic Activity (OPA) 92%

Mucosal Challenge Density 45 Diplococci

Population Dynamics & Serotype Ratio

Vaccine Targeted (VT): 0 cells

Non-Vaccine Escape (NVT): 0 cells

Macrophage Engulfments: 0 total