Zinc Cellular Transport & Apoptosis Simulator

Prostate Carcinoma State

ZIP Channel Density (Import) 0.15

ZnT Channel Density (Export) 0.80

Extracellular [Zn²⁺] (µM) 15 µM

Aconitase / Citrate Switch

Toggle active citrate oxidation vs zinc block

Live Telemetry

Intracellular Free [Zn²⁺]

0.40 nM

Apoptosis Rate

4.2%

Caspase-3 Gate

INACTIVE

mPTP Pore State

CLOSED

Higher cytoplasmic zinc binds mitochondrial aconitase, arresting citrate oxidation, triggering ROS spikes and opening membrane mPTP pores to force cell death.

Actions & Persistence

STATE: carcinoma_proliferation | FREE_ZN: 0.40 nM | APOP_RATE: 4.2% | mPTP: false