Adrenaline Cascade Simulator

Epinephrine Receptor Binding & Physiological Signaling Simulator
2D Cell Membrane & Signal Transduction View
Click Canvas to Inject Epinephrine
Epinephrine (Ligand)
Beta-Receptor
G-Protein (α-GTP)
cAMP Enzyme
Active PKA
Beta-Blocker
Peak cAMP: 18.4 uM
PKA Activated: 82.5%
Peak Heart Rate: 145 BPM
Glucose Release: 28.2 mg/dL/min
Downstream Organ Systems LIVE
Heart Rate
145
BPM
Contractility
+45.2
% change
Glucose Release
28.2
mg/dL/min
Vasodilation
+38.0
% Skeletal Muscle
Molecular Parameters
Epinephrine Dose 50 nM
Receptor Density 120 /μm²
PDE Inhibitor (Caffeine/Theophylline) 0%
Beta-Blocker Competition 0 nM
Signal Transduction Chain
1. Epinephrine Binding (β1/β2)
2. G-Protein (Gαs) Dissociation
3. Adenylate Cyclase & cAMP Sync
4. PKA Activation & Phosphorylation

A saved cascade model has saturation, rounding and peak labels

Read the explanation

This explains a saved numerical demonstration rather than medical dosing, physiology validation or treatment advice. Effective input is floored at zero after subtracting zero point eight times the blocker input. With input fifty and blocker zero, effective input is fifty; with blocker fifty it is ten; with blocker one hundred it is zero. At five pixels per input unit, the bars are two hundred fifty, fifty and zero. The receptor fraction divides this value by itself plus twenty, scales by density over one hundred twenty, rounds and caps at one hundred. Every displayed consequence is downstream of this simplified formula. At effective input fifty and density one hundred twenty, receptor occupancy rounds to seventy one. G protein is ninety five percent of that, giving sixty seven point four five. Multiplying by zero point two two gives fourteen point eight three nine before rounding to fourteen point eight for the next variable. At four pixels per numerical value, the receptor and G protein bars measure two hundred eighty four and two hundred sixty nine point eight, while the rounded downstream value measures fifty nine point two. The formula uses chosen constants and staged rounding; it is not calibrated evidence of a biochemical concentration in a person. The next activation multiplies fourteen point eight by four point five, giving sixty six point six percent, capped at ninety eight point five. Heart-rate display rounds seventy two plus eighty eight times that fraction, giving one hundred thirty one. The saved proof labels for concentration and heart rate show historical maxima initialized at eighteen point four and one hundred forty five. They can remain above these current calculated values. At two pixels per heart-rate unit, current one hundred thirty one measures two hundred sixty two, while saved peak one hundred forty five measures two hundred ninety. A peak label is not the current output and does not validate an actual physiological response.

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