Endocrine Axis & Receptor Physiology Simulator

Hypothalamic-Pituitary Kinetics & Cellular Saturation Model
Stage Presets:
HPG / HPA Axis Feedback Network
E2
P4
Cortisol
Pulse frequency represents pituitary gonadotropin drive (FSH/LH). Thick dashed lines indicate negative feedback loops.
Target Cell Membrane Kinetics
Receptor Occupancy:0%
Binding Rate (Kd):1.2 nM
State:Starvation
Particles collide with transmembrane receptors. Bound receptors trigger intracellular downstream cascade flares.
Hormone Concentration Adjusters
Direct manual manipulation overrides active preset values
Estradiol (E2) 18 pg/mL
Progesterone (P4) 0.4 ng/mL
FSH (Follicle-Stimulating) 65 mIU/mL
LH (Luteinizing) 42 mIU/mL
Cortisol 250 nM
Symptom & Receptor Decoder
Perimenopause Pattern Active
Vasomotor Stability (Hot Flashes) Moderate Instability
Hypothalamic KNDy neuron hyperactivity triggered by withdrawal of estrogenic negative feedback, narrowing the zone of thermoregulatory threshold.
Neurosteroid & GABA-A Modulation Attenuated
Progesterone neurosteroid metabolites (allopregnanolone) normally enhance GABA-A inhibition. Low levels disrupt sleep architecture & mood resilience.
Bone Remodeling Ratio (RANKL/OPG) Resorption Bias
Estrogen induces osteoclast apoptosis. Low ER-alpha receptor occupancy increases RANKL expression, accelerating bone mineral density depletion.