Clinical kinetics simulator auditing extreme AI-generated deficit diets (ICU crash case: 20 kg / 45 days)
Severe hypokalemia & arrhythmia hazard
Severe nitrogenous urea & ketone clearance demand
In severe caloric starvation diets, the body cannot fuel total energy expenditure through adipose tissue alone. Adipose tissue mobilizes approximately 68 calories per kilogram daily. When an extreme deficit exceeds this cap, systemic muscle catabolism surges. Selecting the Clinical Safe preset raises intake to 1950 calories, keeping the deficit within physiological boundaries and preserving vital lean tissue.