Pharmacokinetics & Neuroadaptation Simulator
D3 Engine
Post-Incident Escalation
Daily Evening Binge
Gradual Taper
Reset
Physiological Profile
Sex
Male (r = 0.68)
Female (r = 0.55)
Weight (kg):
75
Gastric State
Fasted (Rapid Ka: 3.0/h)
Fed/Meal (Delayed Ka: 1.2/h)
Clearance Rate
Slow (0.012%/hr)
Normal (0.015%/hr)
Induced (0.020%/hr)
Drink Events (Multi-Day)
+ Add Drink
Sim Horizon:
72
hours
Continuous BAC & Neuroreceptor Dynamics
Hover timeline for cross-section
Peak BAC
0.114%
Hours to Zero BAC
7.6h
GABA/NMDA Imbalance
1.42x
Withdrawal Risk
Moderate
BAC (% g/dL)
GABA-A Sensitivity (Internalization)
NMDA Receptor Density (Up-regulation)
Rebound Hyper-Excitability Zone
Harm Reduction Taper
Compare abrupt cessation rebound excitotoxicity vs. structured enzymatic step-down.
Taper Target Duration
3 Days (Rapid Step)
5 Days (Standard Clinical)
7 Days (Gentle Harm Reduction)
Compute Taper Regimen
Day
Target Drinks
Peak Est.
NMDA Load
Telemetry & Export
Export JSON
Export CSV
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