Parameters & Dosing
0.40
70
100%
Pharmacokinetic Mechanism
IV bolus administration bypasses first-pass hepatic monoamine oxidase (MAO-A) degradation, yielding rapid peak plasma concentration within 2 minutes ($T_{\max}$). Continuous clearance via peripheral MAO-A yields a brief plasma elimination half-life ($t_{1/2} \approx 15\text{ min}$).
Peak Plasma ($C_{\max}$)
82.4 ng/mL
Time to Peak ($T_{\max}$)
2.0 min
Elimination $t_{1/2}$
15.0 min
5-$HT_{2A}$ Peak Occ.
78.5%
$\Sigma_1$ Peak Occ.
34.2%
Plasma & Brain Clearance Time-Course ($0 - 60\text{ min}$)
— Plasma · · · CNS Target
Receptor Occupancy Trajectory
5-$HT_{2A}$ & $\Sigma_1$ Equilibrium State
Active Model Context & Evidence Summary
Dataset fully populated with Strassman (1994/1995) reference benchmark kinetics.