Endocrine Lab

Androgen Receptor Signaling & DSD Simulator

CLINICAL PRESETS:
2D Molecular Kinetics & Receptor Activation
Testo (T)
DHT
AR Receptor
Active Complex
AR Affinity (Kd)
0%
Active Complexes
0
Transcription Output
0.0%
DHT Ratio
0.0%
Testosterone Level 600 ng/dL
5α-Reductase Activity 100%
AR Binding Affinity (Kd) 0%
AR Receptor Density 100%
Embryonic Tissue Morphogenesis (6–12 Gestational Weeks) 46,XY Genotype
Gestational Timeline Scrubber Week 8
INTERNAL DUCTS EXTERNAL GENITALIA Testis Wolffian Duct (Regressed) Müllerian Duct (Regressed) Female Phenotype MIS present → Müllerian regression. Low AR binding → Wolffian regression & Female external genitalia.

CAIS (Complete Androgen Insensitivity)

Despite a 46,XY genotype and functional testes producing testosterone & MIS (Müllerian Inhibiting Substance), complete AR non-responsiveness (Kd = 0%) prevents Wolffian duct survival and external virilization. Müllerian ducts regress normally due to MIS, resulting in female external genitalia, unvirilized phenotype, and absent internal uterus/ovaries.

CANONICAL COMPUTED RESULT:
Preset: CAIS
Karyotype: 46,XY
AR Kd: 0%
Transcription: 0.0%
Wolffian: Regressed
External: Female
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