Biliary Pathophysiology & Cholangiocarcinoma Explorer

Anatomical Flow Simulation Perihilar (Klatskin)

Tumor Subtype

Duct Occlusion (%)

75%

Healthy Flow Particles

Engorged / Stagnant Bile

Tumor Site (Occlusion)

Pathophysiological Impact: Significant obstruction at the hepatic duct confluence causing upstream intrahepatic biliary tree dilation (hydrohepatosis), impaired clearance, and elevated serum bilirubin.

Total Bilirubin

4.2

mg/dL (0.2–1.2)

Elevated

Alk Phos (ALP)

380

U/L (44–147)

Marked High

CA 19-9

320

U/mL (<37)

High Risk

CA 19-9 Elevation Kinetic Curve

MRCP Projection: T2-weighted MRI simulation highlighting fluid-filled biliary structures. Duct dilatation appears hyperintense (bright white), while strictures/tumors manifest as signal loss or abrupt caliber change.

Cholangiocarcinoma exhibits distinct genomic profiles based on anatomical subtype. Targeted therapies offer precision intervention.

Simulated Diagnostic State: Perihilar cholangiocarcinoma at 75% occlusion. Projected serum Bilirubin: 4.2 mg/dL, CA 19-9: 320 U/mL. Primary Genomic Target: FGFR2 Fusions.