Pancreatic Cancer Clinical Survival & Stroma Transport Simulator

Experimental Median OS

14.2 mo

+5.7 mo vs baseline

Hazard Ratio (HR)

0.62

p < 0.001

2-Year OS Rate

28.4%

Baseline: 9.8%

Stroma Clearance Index

0.71

Perfusion: 68%

Number Needed to Treat

5.4

at 24 Months

Clinical Trial Presets

Trial Parameters

Hazard Ratio (HR) 0.62

Baseline Median OS (mo) 8.5

Cohort Size (N per arm) 500

Tumor Microenvironment

Stroma / Collagen Density 75%

Vascular Permeability 65%

Follow-up Window 36 mo

Kaplan-Meier Overall Survival (OS) 95% Hall-Wellner Band

Experimental Arm

Historical / Control Arm

PDAC Stroma Barrier & Drug Perfusion 68% Penetration

Ductal Cells

Stroma Fibers

Drug Molecules

Survival Timeline & Patients At Risk

Month	Exp At Risk	Exp Survival (95% CI)	Ctrl At Risk	Ctrl Survival	Absolute Gain	NNT