Dual-Track Developmental Scrubber
Coupled Gestational Sync
In Vivo Gestation (Human Fetal Brain)
PCW 18 (Post-Conception Week)
In Vitro Culture (Days In Vitro)
DIV 120 (Days In Vitro)
Cell Fate Trajectory & Stratification
SOX2+ Progenitors
TBR1+ Deep Layers (V/VI)
SATB2+ Upper Layers (II-IV)
GFAP+ Astrocytes
Metabolic Core Stress & Clock Skew
Core HIF1A Stress
Organoid Clock Bias
In Vivo Normal Baseline
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Culture Intervention Simulator
Clock Divergence
-16 d
Early deep-layer skew
Fidelity Score
59%
Moderate Drift
Metabolic Stress (HIF1A)
0.64
Core Hypoxia Elevated
Glial Switch Phase
Premature (DIV 90)
In vivo equivalent: PCW 26
Disease Modeling Validity Windows
| Disease Model | Optimal Window | Status |
|---|