CRISPR Base Editing Roadblock Simulator

UW-Madison 19,144-Gene Screen: Resolving Competitive DNA Repair Flux

19,144 Genes Screened

Molecular Target & Deamination R-Loop

52.1%
Editing Efficiency
6.2x
Fold Increase
1.8%
Indel Byproduct
Desired Transition (Productive Edit): 52.1%
BER/MMR Reversion Flux (Roadblock): 46.1%

19,144-Gene Screen Triage & Knockout Matrix

Top 6 Screened Roadblocks 19,138 Neutral/Other Genes

Toggle targeted disruptions to suppress competing repair pathways:

Simulated Target Locus Trace: ATGCGATCGGTACTA Product Purity: 96.7%
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