Ebola Variant Outbreak Response Workbench

Accelerate field epidemiology and intervention logistics during outbreaks of atypical filovirus clades. Model transmission dynamics, ring-vaccination coverage, diagnostic turnaround, and monoclonal therapy efficacy.

Epidemiological Trajectory & Field Telemetry

DRC Health Ministry / CEPI Operational Model
Effective Re (Day 45)
0.82
Controlled (Re < 1.0)
Projected Cumulative Cases
142
± 18 variance window
Expected Fatalities
44
31.0% Case Fatality Rate
Vaccine Doses Required
3,850
28 ring containment zones
Active Infectious (I)
Exposed / Incubation (E)
Ring Vaccinated & Immune (V)
Cumulative Mortality
Simulation converged. 45-day projections calibrated to INRB field data.
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INRB Genomic Surveillance

Kinshasa and field laboratories in Goma employ rapid nanopore genomic sequencing to detect filovirus clade divergences in real time, determining whether standard rVSV-ZEBOV vaccines or monoclonal cocktails require rapid reformulation.

WHO AFRO Ring Logistics

Ring vaccination targets contacts of confirmed index cases plus secondary contacts. Speed is vital: delivering ultra-cold chain doses within 72 hours of symptom exposure collapses community reproductive numbers below the critical threshold.

CEPI Rapid Response

Pre-stocked clinical trials and adaptive investigational protocols enable global health partners to trial next-generation multi-clade vaccines and pan-ebolavirus neutralizers without delaying acute patient stabilization.

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