Endosomal Recycling & FcRn Blockade Micro-State
FcRn Receptors
Pathogenic IgG
Efgartigimod (Vyvgart)
Lysosome Degradation
Calculated Pharmacodynamic Telemetry
IgG Reduction
68.5%
3.9 g/L remaining
Lysosomal Degradation
4.2x baseline
FcRn Saturated: 86%
ACR/EULAR TIS Score
42.8
Major Clinical Response (TIS >= 40)
MMT-8 Muscle Strength
68.4 / 80
+10.4 from baseline
24-Week Pharmacodynamic Trajectory (Serum IgG vs TIS)