Flavanone Neurovascular Flow & Cognition Simulator

Microvascular Arteriole & Capillary Bed (eNOS Dilation & RBC Flow) ● eNOS Active

Cerebral Blood Flow 57.2 mL/100g/min

Executive Latency 348 ms (-15.5%)

Flavanone Intake (Hesperidin/Naringin) 200 mg/day (~2 cups OJ)

Simulates citrus flavanone concentration in circulating plasma.

Intervention Timeline 8 Weeks (Chronic)

Chronic intake increases baseline eNOS transcription & microvessel density.

Neural Workload Demand High (Task-Switching)

Triggers localized metabolic ATP demand & neurovascular coupling surge.

Hemodynamic Readout Real-time

Dilated Arteriole Lumen 32.8 µm +15.5% vs baseline

Capillary RBC Velocity 1.82 mm/s +28.2% transit rate

Tissue Oxygen (pO₂) 42.1 mmHg Pyramidal Neurons

Coupling Latency 1.40 s -33% hyperemia delay

Executive Task Battery Switching Test

STAGE: READY

Click "Trigger Cognitive Challenge" to run reaction latency test.

Task Latency 348 ms -64 ms vs ischemic baseline

Cognitive Gain +15.2% Global Composite Score

Flavanone Perfusion State

Chronic daily intake (~200mg flavanones over 8 weeks) activates endothelial eNOS phosphorylation, widening microvascular arterioles to 32.8 µm. Improved neurovascular coupling reduces executive latency to 348 ms.