Baylor Trial Model Michaelis-Menten Enzymatic Engine

GlyNAC Glutathione Synthesis & ROS Kinetics Simulator

Explore cysteine rate-limitation & glycine saturation kinetics on mitochondrial membrane potential (ΔΨm) and intracellular GSH restoration.

Clinical Presets:

Precursor Flux & Cell Parameters Live Reaction Inputs

Baseline Cellular State:

Glycine Flux (mM): 1.00 mM

Glutathione Synthetase (GS) rate-limiting substrate

NAC / Cysteine Flux (mM): 0.80 mM

γ-Glutamylcysteine synthetase (GCL) primary bottleneck

Baseline ROS Production (μM/s): 0.45 μM/s

Mitochondrial electron transport chain leak rate

Simulation Horizon (Hours): 24 hrs

Primary Bottleneck Relieved: Cysteine availability (via NAC) & GS saturation (via Glycine)

Baseline GSH 1.15 μM

Supplemented GSH 2.85 μM

ROS Neutralization 78.4%

Membrane Potential (ΔΨm) -158.2 mV

GSH GSSG ROS

Outer Membrane → Intermembrane Space → Matrix ΔΨm Stability: -158.2 mV

Differential Solver: 24h Course

GSH Pool (μM) Free ROS Concentration GSSG Recycled