Gut Microbiome Dysbiosis & Resection Simulator Harvard HSPH Grounded

Timeline & Interventions

Post-Resection Horizon Year 10
Dietary Fiber Intake 14 g/day
Probiotic Supplementation 0 CFU/day
Inflammatory Status (Cytokines) 3.8 Index
Harvard HSPH Study Insight: Microbiome dysbiosis persists 10+ years post-adenoma removal. Low butyrate producers (e.g. F. prausnitzii) and elevated opportunists (F. nucleatum) drive long-term recurrence risk if unmanaged.
Interactive Epithelium Cross-Section
Animate cell dynamics, mucosal mucus layer, & particle fluxes
F. nucleatum
F. prausnitzii / Roseburia
Akkermansia
Butyrate Flux
10-Yr Recurrence Risk
48.2%
Elevated Risk
Butyrate Deficit
-46.5%
8.4 mmol/L
Dysbiosis Persistence
High Dysbiosis
Decadal Shift Index
F. nucleatum Enrichment
3.5x
Pathobiont Fold Shift
Mucosa Integrity
Moderately Compromised
Score: 62.5 / 100

Taxa Composition Relative Abundance (%)

Short-Chain Fatty Acid (SCFA) Yield (mmol/L)