Hepatocyte Micro-Structure Metabolic Circuit
High DNL Active
Fructose
Glucose / Pyruvate
Free Fatty Acids
Triglyceride / VLDL
Directly manipulate inputs to alter flux speeds
Net TG Accumulation Rate
+42.5
mg / g liver / day
Intrahepatic Lipid (IHL)
14.2%
Threshold for NAFLD: > 5.0%
Steatosis Severity
Grade 2
Moderate Steatosis
Target Reversal Time
18.4 wks
Est. to reach < 5% IHL
Substrate & Lifestyle Parameters
HFCS / Refined
Sweet Potato / Fiber
80 g/day
85 %
3.2
0 hrs/wk
Molecular Pathway Bottlenecks
Fructokinase (KHK) Bypass
Unregulated Flux
ChREBP / SREBP-1c Lipogenesis
High Activation
Malonyl-CoA (CPT-1 Inhibition)
Oxidation Blocked
AMPK Substrate Clearance
Low / Suppressed
High Fructose Corn Syrup Baseline Summary
High unbound fructose bypasses phosphofructokinase control in the liver via Fructokinase (KHK), resulting in rapid uncontrolled acetyl-CoA overload. Combined with 85% glycogen saturation, pyruvate is diverted into De Novo Lipogenesis (DNL). Malonyl-CoA accumulation severely inhibits CPT-1, blocking mitochondrial beta-oxidation and forcing lipid droplet storage.