Germinal Center Lineage Tree & Somatic Hypermutation
Naive
Mutating
High Affinity
Clash / Dead
Stage 1: Germline Priming (eOD-GT8 60mer). High avidity nanoparticle engineered to bind rare unmutated naive precursor B cells (frequency ~1 in 100,000) lacking CD4-binding site maturity.
Env Trimer Epitope Docking & Global Neutralization Panel
Tier 2/3 Resistant Focus
Target Epitope
CD4bs
bNAb Lineage
VRC01-class
SHM Mutations
0
Lineage Survival
100.0%
Neutralization Breadth
0.0%
Mean IC50 (µg/mL)
>50.0
Global HIV-1 Pseudovirus Panel Neutralization