Clonal Selection & Mutational Landscape
Stage 1: Germline Priming
Dose 1 (Prime)
eOD-GT8 60mer
Dose 2 (Shepherd)
Core-g28v2
Dose 3 (Polish)
BG505 SOSIP Trimer
Germline Targeting Mechanism: Engineered 60mer nanoparticle with nanomolar affinity to rare germline precursors (VH1-2*02 alleles) engages naive repertoire, triggering initial germinal center recruitment without off-target distraction.
Lineage Evolution Telemetry
Cycle: 4/15
Potent VRC01-Class bNAb Lineage Evolved
Sequential Guide
Clade Neutralization Breadth
83.3%
10 / 12 Global Isolates
Germline Recruitment Rate
89.4%
Target Precursors Primed
Mean SHM V-Gene Divergence
18.6%
CDRH3 loop mature
Off-Target Immunodominance
12.4%
Non-neutralizing suppressed
Global HIV-1 Clade Neutralization Assay
Tier 2 Neutralization High
Target Epitope: CD4 Binding Site (CD4bs)
Precursor Freq: ~1:300,000