Prevotella Airway Oxygen Dynamics Simulator | Microaerotolerant Kinetics

Microhabitat Setup U-M Research Grounded

Anatomical Niche Preset

Oxygen Concentration (O₂) 6.2%

Mucus Barrier Depth 150 µm

Incubation Duration 12.0 hrs

Initial Inoculum (CFU) 1,000 CFU

Antioxidant Defense Factor 1.25x

Kinetic Comparison Mode

Airway Mucus Cross-Section & Cell Lattice Live Active Cells

Depth: 150 µm | Local O₂: 6.2%

Dividing

Basal

Stress Pigment

Lyzed / Inert

12-Hour Population Trajectory (CFU vs Time) Empirical (Cyan) vs Strict Dogma (Rose)

Kinetic Telemetry Active Growth

Growth Rate (µ) 0.48 dbl/hr Monod Microaerobic

12hr CFU Count 42,800 Empirical Population

Enzyme Defense 78.5% Peroxidase/Catalase

Oxidative Stress 0.14 /hr ROS Accumulation

Hypoxia Index 0.72 Tissue Gradient Factor

21% O₂ Half-Life 18.4 hrs Atmospheric Survival

Empirical Paradigm Contrast

Historical Dogma (100yr): Extinction in >2% O₂

U-M Empirical Finding: Active division at 5–8% O₂

Atmospheric 21% O₂: Transient survival >12-24h

Reference: University of Michigan study reported by Phys.org overturning century-old taxonomy of Prevotella melaninogenica as an obligate strict anaerobe in human lungs.