Nutrigenomics Evidence & Trait Analyzer

Genetic Marker Selector

Single-Gene Variations vs. Dietary Response

LCT / MCM6 (rs4988235) High Scientific Evidence

Controls lactase persistence into adulthood. Predicts dairy lactose tolerance.

CYP1A2 (rs762551) High Scientific Evidence

Hepatic cytochrome P450 enzyme rate. Determines caffeine clearance half-life.

ACTN3 (rs1815739) Moderate Trait Evidence

Alpha-actinin-3 structural protein in fast-twitch skeletal muscle fibers.

VDR (FokI / TaqI) Moderate Evidence

Vitamin D nuclear receptor affinity and downstream bone/calcium regulation.

Diet & Metabolic Goal

Physical Activity Level

Scientific Validity & Recommendations

Monogenic Truth vs Commercial Oversell

Validated Monogenic Genetics Commercial Marketing Overreach

Slide to inspect how adding speculative multigenic "DNA diet" claims dilutes actionable clinical precision.

Primary Insight

Lactose tolerance confirmed and moderate caffeine clearance noted; genetic profile suggests standard balanced macros rather than specialized DNA diet restrictions.

Actionable Clinical Recommendation

Use single-gene insights for dairy and caffeine adjustments while prioritizing overall caloric balance and activity level for weight management.

Scientific Caveats & Evidence Audit

Actionable Single-Gene Insights: Focuses on well-established gene-trait interactions like lactose intolerance (LCT) and caffeine metabolism (CYP1A2).
Lactose Tolerance Confirmed: LCT gene variations accurately predict lactase persistence.
Moderate Caffeine Clearance: CYP1A2 AC variant clears caffeine at medium rates; avoid pre-bed stimulants after 2 PM.
Standard Balanced Macros: Genetic profile suggests general balanced macronutrient needs rather than highly specialized DNA diet restrictions.
Commercial Marketing Overreach: Broader claims that DNA prescribes strict metabolic macronutrient splits (e.g. keto vs low fat) have been refuted in 600+ person Stanford trials (DIETFITS).