Orexin Neurocircuit Explorer OX1R / OX2R Kinetics

Hypothalamic-Monoaminergic Flip-Flop Circuit System State: Wake Stabilized

Pharmacology & Circuit Controls

LH Orexin Neurons: 70,000

Sleep Pressure (Adenosine): 25%

Circadian Arousal Drive: 80%

Drug Compound: Endogenous Only

Compound Dose (mg): 0 mg

Real-Time Kinetics & State

Arousal State CONSOLIDATED WAKE

Vigilance Index 88%

OX1R Occupancy 0%

OX2R Occupancy 0%

VLPO GABA Output 12 Hz

Cataplexy Barrier Secure (94%)