Clinical Scenarios
Pharmacology & State
Receptor Target
Hypothalamic Bistable Flip-Flop Circuit
Arousal Spikes (LC/TMN/DR)
SOPN/VLPO Firing Rate
Telemetry & Stability
OX2R Occupancy
0.0%
Switch Stability Margin
+84%
Cataplexy Protection
Normal
Mean Sleep Latency
18.5 min
Phase Plane Attractor
Mechanism Summary: Orexin/Hypocretin neurons in the Lateral Hypothalamus stabilize the ascending monoaminergic system, preventing inappropriate VLPO-mediated sleep intrusions during behavioral wakefulness.