Orexin Wakefulness Circuit & Agonist Simulator

Arousal Vigilance

88.4%

OX2R Occupancy

64.2%

Monoamine Firing (Arousal)

24.5 Hz

VLPO Sleep Nucleus

3.2 Hz

Clinical Presets

Pharmacology & Titration

OX2R Agonist Dosage 0 mg

Intact Orexin Neurons 70,000

Agonist Affinity (Kd) 1.4 nM (High)

Homeostatic & Circadian Drives

Adenosine (Sleep Pressure) 0.25 kPa

SCN Circadian Arousal 85%

Mechanism: Orexin-A/B peptides from the lateral hypothalamus excite monoaminergic arousal nuclei (LC, TMN, DR), driving mutual reciprocal inhibition of GABAergic VLPO neurons to stabilize the bistable flip-flop switch.