Physiological ADME Pipeline Simulation
Live Kinematics
How does a tablet find your pain? Oral drugs do not actively navigate to pain. They dissolve in the stomach, undergo first-pass hepatic metabolism, and enter systemic circulation. As blood flows everywhere, molecules randomly collide with receptors; high target affinity causes selective docking at inflamed COX-2 pain sites!
Blood Plasma Concentration & Pharmacokinetics
Cmax (Peak Conc)
24.6μg/mL
Tmax (Time to Peak)
1.2hrs
Half-Life (t½)
2.1hrs
AUC Exposure
142.8μg·h/mL
Bioavailability (F)
82.5%
COX-2 Occupancy
78.4%
COMPUTED PK PROOF STATE:
Cmax: 24.6 μg/mL | Occupancy: 78.4%
Simulating Active ADME