Micro-Compartment Kinetic Flow
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Intact mRNA Strand
LNP Shell Barrier
Active RNase / Acid Hydrolysis
Cleaved Mononucleotides
Intact Oral Fraction
2.00e-6
Stomach Degradation
99.85%
Intestinal Cleavage
99.9999%
Systemic Bioavailability
0.00%
Verified Kinetic Result & Biological Proof
Mammalian digestive enzymes (salivary RNase A, gastric acid pH 1.5, pancreatic nucleases) degrade 99.9998% of ingested mRNA within seconds, resulting in 0.00% systemic tissue bioavailability.
Physiological & Spray Parameters
Gastric Acid pH Level
1.5
Salivary RNase Activity
150 U/mL
Pancreatic RNase Activity
800 U/mL
LNP Shell Thickness
5 nm
Foliar Spray Dose
500 µg/kg
Comparative Biological Barriers
Mammalian Human Digestive Barrier
Rapid degradation via endo- and exonucleases in saliva, acid-catalyzed depuration in stomach, and complete phosphodiester cleavage by pancreatic enzymes in intestine prevents any intact systemic absorption.
Target Agricultural Pest Midgut
Alkaline midgut pH combined with specialized transmembrane dsRNA transporters (e.g., SID-1 analogs) allows targeted cellular uptake and RNAi gene silencing exclusively in specific target insects.