Vaccine Safety Evidence & Adverse Event Signal Analyzer

Objective Evidence Synthesis: Evaluating unverified spontaneous reporting (VAERS) against controlled peer-reviewed cohort studies across 10M+ patient-years.

Methodology: GRADE & Cochrane Risk of Bias

Signal Selection & Filters

Signal Dataset Preset

Observed Relative Risk (RR) 1.02

1.0 = Exact null effect / no increased risk

95% CI Lower Bound 0.95

95% CI Upper Bound 1.09

Total Sample Size (N) 1,250,000

Peer-Reviewed Controlled Studies 42

VAERS / Spontaneous Reports 1,420

Signal Verification Metrics Validated Safe

Signal Strength Score

1.4

0.0 (Null) - 10.0 (High)

Statistical Significance

Not Significant (Null Effect)

p = 0.62 (95% CI includes 1.0)

Risk of Bias Rating

Low (Large-Scale Controlled Studies)

GRADE Methodology

Consensus Status

Overwhelming Epidemiological Consensus

Global Health Bodies

D3.js Evidence Matrix: Sample Size vs Relative Risk (with 95% CI)

Side-by-Side Signal Ledger: Claim vs Empirical Cohort

Evidence Dimension	Spontaneous Unverified Claims	Controlled Peer-Reviewed Studies	Statistical Variance
Cohort Scale	1,420 unverified event submissions	1,250,000 verified patients across 42 trials	880x higher statistical power
Relative Risk (RR)	Uncontrolled temporal association	1.02 (95% CI: 0.95 - 1.09)	Null difference from unexposed cohort
Confounding Control	Zero adjustment for baseline age/health	Multivariable propensity score matching	Eliminates reporting & selection bias
Diagnostic Verification	Self-reported or unconfirmed notes	Independent clinical chart adjudication	Gold-standard phenotypic validation

Audited Verification Result: Current biostatistical evaluation confirms MMR Vaccine & Autistic Spectrum Disorder Risk holds a relative risk ratio of 1.02 over 1,250,000 subjects, validating safety and rejecting causal association.

Epidemiological Sources & Literature Foundations:

Madsen KM, et al. A Population-Based Study of Measles, Mumps, and Rubella Vaccination and Autism. N Engl J Med. 2002. (Sample: 537,303 children).
Hviid A, et al. Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study. Ann Intern Med. 2019. (Sample: 657,461 children).
CDC / FDA Vaccine Adverse Event Reporting System (VAERS) User Guide: Spontaneous reports represent temporal associations, not causality.