Cohort & Event Parameters
Loads validated clinical trial and surveillance baseline presets.
Estimated severe disease outcomes averted in this cohort.
Epidemiological Equations
Observed vs Expected (O/E)
Expected Events ($E$) = Cohort $\times$ (Background Rate / 100,000) $\times$ (Days / 365).
Reporting Odds Ratio (ROR)
Disproportionality measure comparing reported cases in exposed vs non-exposed background reporting databases.
Time-to-Onset Distribution (14-Day Window)
Risk-Benefit Trade-off (per 1,000,000)
Calculated Statistical Evidence Table
| Metric Parameter | Calculated Value | 95% Confidence Interval | Interpretation |
|---|---|---|---|
| Expected Background Events ($E$) | 0.805 | [0.32 - 1.66] | Expected baseline cases in unexposed cohort |
| Observed Reported Events ($O$) | 42 | [30.12 - 56.88] | Actual reported post-vaccination cases |
| Observed-to-Expected (O/E) Ratio | 52.17 | [37.76 - 70.43] | Statistical signal flag if lower CI > 1.0 |
| Excess Cases per Million Doses | 41.20 | - | Attributable risk window incidence |
| Prevented Severe Outcomes / Million | 640.00 | - | Disease hospitalizations averted |